Total mesopancreas excision is the better staging tool of the mesopancreas in pancreatic head carcinoma

Preoperative imaging staging based on tumor, node, metastasis classification cannot be effective to avoid R1 resection because only further improvements in imaging technologies will allow the precise assessment of perineural and lymphatic invasion and the occurrence of microscopic tumour deposits in the mesopancreas. However, waiting for further improvements in imaging technologies, total mesopancreas excision remains the only tool able to precisely assess mesopancreatic resection margin status, maximize the guarantee of radicality in cases of negative (R0) mesopancreatic resection margins, and stage the mesopancreas.     

Inlay‐retained cantilever fixed dental prostheses to substitute a single premolar: impact of zirconia framework design after dynamic loading

The purpose of this in‐vitro study was to evaluate the influence of the framework design on the durability of inlay‐retained cantilever fixed dental prostheses (IR‐FDPs), made from zirconia ceramic, after artificial ageing. Forty‐eight caries‐free human premolars were prepared as abutments for all‐ceramic cantilevered IR‐FDPs using six framework designs: occlusal–distal (OD) inlay, OD inlay with an oral retainer wing, OD inlay with two retainer wings, mesial–occlusal–distal (MOD) inlay, MOD inlay with an oral retainer ring, and veneer partial coping with a distal box (VB). Zirconia IR‐FDPs were fabricated via computer‐aided design/computer‐aided manufacturing (CAD/CAM) technology. The bonding surfaces were air‐abraded (50 μm alumina/0.1 MPa), and the frameworks were bonded with adhesive resin cement. Specimens were stored for 150 d in a 37°C water bath during which they were thermocycled between 5 and 55°C for 37,500 cycles; thereafter, they were exposed to 600,000 cycles of dynamic loading with a 5‐kg load in a chewing simulator. All surviving specimens were loaded onto the pontic and tested until failure using a universal testing machine. The mean failure load of the groups ranged from 260.8 to 746.7 N. Statistical analysis showed that both MOD groups exhibited significantly higher failure loads compared with the other groups (i.e. the three OD groups and the VB group) and that there was no significant difference in the failure load among the OD groups and the VB group. In conclusion, zirconia IR‐FDPs with a modified design exhibited promising failure modes.     

PVC/PE/PVDC固体药用复合硬片PVDC涂布量测定

目的 建立一种测定聚氯乙烯/聚乙烯/聚偏二氯乙烯（PVC/PE/PVDC）固体药用复合硬片PVDC涂布量的方法。方法 裁取10 cm×10 cm的样品5片,将样品先在丙酮中浸泡,分离得到PVC层和PE/PVDC复合层。将PE/PVDC复合层于80℃中干燥2 h后,于23℃放置4 h,精密称定。再将PE/PVDC复合层在四氢呋喃中浸泡,使PVDC层溶解在四氢呋喃溶液中,得到PE膜层,于80℃中干燥2 h后,于23℃放置4 h,精密称定,前后2次差值即为PVDV质量（g）。最后计算PVDC涂布量（以g·m^-2表示）。结果 5批样品PVDC涂布量测定结果与标示涂布量均一致,且偏差均在±5%之内。结论 该方法准确、灵敏,适用于PVC/PE/PVDC固体药用复合硬片PVDC涂布量的测定。     

高压液相色谱技术分离制备杆菌肽各组分的研究

目的 开发制备型高压液相色谱分离杆菌肽各组分的方法.方法 根据杆菌肽各组分化学结构性质,采用纳微UnisilC1s柱,通过改变流动相pH和流动相配比,以及不同的上样量,探索杆菌肽各组分分离的方法.收集分离得到的不同组分,经脱盐-冷冻干燥,得到相应杆菌肽组分冻干粉.结果 纳微Unisil C18柱可以用于杆菌肽各组分的分离,流动相配比为甲醇(A)∶[1.54‰乙酸铵水溶液(乙酸调pH至5.0)-乙腈(9∶1,V/V)] (B)=9.0∶ 11.0(V/V),总流速40 mL· min-1,上样量200mg,检测波长为254 nm.制备得到的杆菌肽各组分纯度均大于95％.结论 该方法上样量大,稳定性好,收集到的各组分纯度高,为杆菌肽各组分的分离制备提供了借鉴.     

蚓激酶口服固体制剂质量分析

摘 要 目的：评价蚓激酶口服肠溶制剂的质量现状及存在问题,为质量标准的提高和临床用药提供参考,同时促进厂家完善产品质量。方法: 按照国家评价性抽验的总体要求,在法定检验方法检验的基础上,开展以下探索性研究,测定样品的重金属残留、蚓激酶的酶学性质分析、蛋白质来源确证与成分分析、近红外光谱模型。统计分析蚓激酶口服肠溶制剂的质量现状并进行评价。结果: 按照法定标准检验,结果显示78批次蚓激酶口服肠溶制剂均符合规定,合格率为100%。探索性研究结果显示来源不同企业的蚓激酶原料中的5种重金属考察,铅、铜、砷、镉均有检出,平均检出量分别为0.4 mg·kg-1,8.4 mg·kg-1,4.4 mg·kg-1与3.4 mg·kg-1;证实蚓激酶具有纤维蛋白溶酶及纤维蛋白溶酶原激酶两种酶活性并建立测定方法;建立了纤维蛋白 聚丙烯酰胺电泳方法检测纤溶活性蛋白质;确证了蚓激酶的来源,并在各企业的样品中鉴定出8～9种溶纤活性相关的蛋白质组分。结论: 根据现行标准检验及探索性研究结果,蚓激酶口服肠溶制剂总体合格率较好,现行标准需提高,生产企业需规范蚯蚓养殖管理过程并建立统一的原材料蚯蚓的质量标准。     

奥硝唑口腔溃疡液配制及质量控制

目的研究奥硝唑口腔溃疡液的制备并对其质量进行控制.方法以奥硝唑为主药制成口腔溃疡液,用高效液相色谱法测定制剂的含量.色谱柱为C18(4.6 mm×250 mm,5 μm),流动相为甲醇-水(30∶ 70),流速1.0 ml·min-1,检测波长318 nm,柱温25℃.并建立制剂的其它质控指标.结果奥硝唑在0.04～0.40μg范围内峰面积与浓度呈良好的线性关系(r=0.9999),平均回收率为99.76%,RSD为0.47%(n=5).结论该制剂配制简单,质量可控.     

5-Fu缓释剂局部埋植治疗卵巢癌腹膜后转移的实验研究

目的探讨植入用5Fu缓释剂局部埋植化疗用于治疗卵巢癌腹膜后转移的可行性。方法建立卵巢癌腹膜后转移动物模型,随机分成三组,腹膜后局部埋植组(A组)埋植5Fu缓释剂2mg,腹腔给药组(B组)注射同等剂量的氟尿嘧啶针剂,空白对照组(C组)腹腔注射生理盐水,观察肿瘤的生物学行为和治疗效果。结果A组较B、C组瘤体积明显减小,重量减轻,荷瘤鼠生存状态提高。结论腹膜后局部埋植5Fu缓释剂对卵巢癌腹膜后转移具有明显的治疗效果,为临床治疗卵巢癌腹膜后转移提供了一种新的治疗方法。     

白蛋白纳米颗粒的制备研究进展

由于可以增强药物的靶向性、降低游离药物的毒副作用,基于纳米颗粒的药物递送系统在医学领域具有广泛应用。白蛋白是血浆中含量最多的蛋白质, 具有生物相容性好、无免疫原性、可生物降解等特性, 是制备纳米颗粒的理想材料。现有白蛋白纳米颗粒的制备方法主要有去溶剂化法、自组装法、乳化法、双乳化法、热凝胶、喷雾干燥、nab^TM技术、pH凝聚法等。由于制备原理及制备条件的差异,各方法表现出的优缺点也不尽相同。综述近年来白蛋白纳米颗粒的制备研究进展, 按照制备方法分类进行介绍, 并对当前白蛋白纳米颗粒研究领域所面临的困境及未来的发展方向进行探讨。     

Preparation of nanocellulose and its potential in reinforced composites: A review

Cellulose is a kind of natural polymer material, which is composed of bundle-like fibrils. By peeling the fibrils layer by layer, the size of cellulose can be nanocrystallized, and nanofibers and nanocrystals with unique and potentially useful features can be prepared. As an emerging functional polymer material, nanocellulose has become a research hotspot in the field of technology. This review discusses the preparation of nanocellulose, including the commonly used hydrolysis, oxidation, physical and environmentally friendly ionic liquid methods. The advantages and disadvantages of different methods are also compared. And the review introduced the application of nanofiberized cellulose and nanocellulose crystals in the fields of thermosetting and thermoplastics, such as polylactic acid, polypropylene, epoxy resin and so on. The critical factors in the manufacturing of nanocellulose composites and mechanical properties are discussed to provide a reference for the further application and development of nanocellulose.